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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
OVERVIEW:
Synonyms | Monoclonal BCL10 antibody, Anti-BCL10 antibody, c-E10 antibody, CARMEN antibody, CIPER antibody, CLAP antibody, mE10 antibody, BCL10, BCL 10, BCL-10, BCL 10 antibody, BCL-10 antibody |
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Cross Reactivity | Human |
Applications | User optimized |
Immunogen | BCL10 antibody was raised in Mouse using full length human recombinant protein of human BCL10 produced in HEK293T cell as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
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Clone | 6A4 |
Isotype | IgG1 |
Method of Purification | BCL10 antibody was purified by affinity chromatography. |
Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5-1 mg/ml |
STORAGE & SAFETY:
Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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Usage Assay Information:
Usage Recommendations | FC: 1:50 |
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GENERAL INFORMATION:
Biological Significance | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. |
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