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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
OVERVIEW:
Synonyms | Monoclonal TP53 antibody, Anti-TP53 antibody, Tumor protein p53 antibody, LFS1 antibody, P53 antibody, Antigen NY-CO-13 antibody, Phosphoprotein p53 antibody, Cellular tumor antigen p53 antibody, Tumor suppressor p53 antibody, TP53, TP 53, TP-53, TP 53 antibody, TP-53 antibody |
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Cross Reactivity | Human, Monkey |
Applications | FC, IF, WB |
Immunogen | TP53 antibody was raised in mouse using a full length recombinant protein of human TP53 (NP_000537) produced in HEK293T cells, as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
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Clone | 5D9 |
Isotype | IgG1 |
Method of Purification | TP53 antibody was purified by affinity chromatography. |
Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 500 ug-1 mg/ml |
STORAGE & SAFETY:
Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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Usage Assay Information:
Usage Recommendations | FC: 1:100, IF: 1:100, WB: 1:500-2000 |
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GENERAL INFORMATION:
Biological Significance | This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, andoligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. |
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