OVERVIEW:

Synonyms	Monoclonal TBXAS1 antibody, Anti-TBXAS1 antibody, Thromboxane A synthase 1 antibody, CYP5 antibody, CYP5A1 antibody, THAS antibody, Cytochrome P450 5A1 antibody, TXA synthase antibody, FLJ52771 antibody, TBXAS1, TBXAS 1, TBXAS-1, TBXAS 1 antibody, TBXAS-1 antibody
Cross Reactivity	Human
Applications	FC, IF, IHC
Immunogen	TBXAS1 antibody was raised in mouse using a full length recombinant protein of human TBXAS1 (NP_001052) produced in HEK293T cells, as the immunogen.

SPECIFICATIONS:

Host	Mouse
Clone	1H9
Isotype	IgG2b
Method of Purification	TBXAS1 antibody was purified by affinity chromatography.
Form & Buffer	Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	500 ug-1 mg/ml

STORAGE & SAFETY:

Storage	Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations	FC: 1:100, IF: 1:100, IHC: 1:50, WB: 1:500

GENERAL INFORMATION:

Biological Significance

TBXAS1 a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion ofprostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke.

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