OVERVIEW:

Synonyms	Monoclonal MAPK8 antibody, Anti-MAPK8 antibody, Mitogen activated protein kinase 8 antibody, JNK1 antibody, SAPK1 antibody, PRKM8 antibody, JNK antibody, Stress-activated protein kinase 1 antibody, JNK1 alpha protein kinase antibody, MAPK8, MAPK 8, MAPK-8, MAPK 8 antibody, MAPK-8 antibody
Cross Reactivity	Human
Applications	WB
Immunogen	MAPK8 antibody was raised in mouse using a recombinant protein expressed in E. coli corresponding to amino acids 1-384 of human JNK1 as the immunogen.

SPECIFICATIONS:

Host	Mouse
Clone	2F10
Isotype	IgG2a
Method of Purification	MAPK8 antibody was purified by affinity chromatography.
Form & Buffer	Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	500 ug-1 mg/ml

STORAGE & SAFETY:

Storage	Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations	WB: 1:1000

GENERAL INFORMATION:

Biological Significance

MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha inducedapoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochromc-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a keyrole in T cell proliferation, apoptosis and differentiation.

Fitzgerald免疫球蛋白是由B细胞产生的大的Y形蛋白质，被免疫系统用来识别和中和细菌和病毒等异物。免疫球蛋白识别每种抗原的独特部分。Y形的每个尖端均靶向外源抗原上的一个表位，从而使两个分子能够以极高的精度结合。使用这种结合机制，抗体可以识别并标记微生物或另一种受感染的细胞，以便受到免疫系统的攻击，或者在某些情况下，通过结合并阻断其一个或多个过程来中和靶标本身。免疫球蛋白的产生是体液免疫系统的主要功能，基于结构和抗原特性有五种不同的类别：IgA，IgD，IgE，IgG和IgM。如果您正在寻找高纯度的产品，高质量的免疫球蛋白及其相关同种型，可用于医学或工业诊断和研究，血清学，ELISA，蛋白质印迹，免疫荧光和其他免疫分析，然后Fitzgerald Industries提供了广泛的免疫球蛋白，可供选择的各种禽类和哺乳动物宿主物种出售。除了五个主要免疫球蛋白类别的纯化效价外，菲茨杰拉德还提供完整的α，β和γIg同种型，异硫氰酸荧光素（FITC），辣根过氧化物酶（HRP）和生物素结合的免疫球蛋白，Fc特异性，Fab和Fab2片段以及也可以提供来自多个宿主物种的重链，轻链，γ和λ链。我们的免疫球蛋白可根据要求与大量宿主一起批量购买或滴定度更小，目标和共轭物，以满足您的需求。我们的免疫球蛋白和抗体范围不断更新，并带有新的靶标，因此请随时与我们联系，以了解您的具体要求。