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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
OVERVIEW:
Synonyms | MonoclonalVEGFantibody,Anti-VEGFantibody,Folliculostellatecell-derivedgrowthfactorantibody,VascularEndothelialGrowthFactorantibody,AntiVEGFantibody,VEGFantibody,VPFantibody,VascularEndothelialGrowthFactorantibody,Folliculostellatecell-derivedgrowthfactorantibody,Glioma-derivedendothelialcellmitogenantibody,Glioma-derivedendothelialcellmitogenantibody,VPFantibody |
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Specificity | Human |
CrossReactivity | Tobedeterminedbyend-user |
Applications | Neutralization,WB |
Immunogen | VEGFantibodywasraisedinmouseusingrecombinanthumanVEGF(E.coli)astheimmunogen |
SPECIFICATIONS:
Host | Mouse |
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Clone | 16F1 |
Isotype | IgG2a |
Source | Ascites |
MethodofPurification | VEGFantibodywasaffinitypurifiedwithproteinA |
Form&Buffer | Lyophilizedproductfrom1%BSAinPBScontaining0.05%NaN3,reconstitutewith1mlofdistilledwater |
STORAGE&SAFETY:
Storage | Storeat4degCuntilreconstitution.Followingreconstitutionaliquotandfreezeat20degCforlongtermstorage |
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UsageAssayInformation:
UsageRecommendations | Neutralisztion:3ug/ml,WB:25ug/ml |
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GENERALINFORMATION:
BIOLOGicalSignificance | VascularEndothelialCellGrowthFactor(VEGF)isahomodimericproteininitiallypurifiedfrommediaconditionedbynormalbovinepituitaryfolliculostellatecellsandsecretedbyavarietyofvascularizedtissues.ItwassubsequentlyfoundtobeidenticaltoavascularpermeABIlityfactor(VPF),whichwaspreviouslyidentifiedinmediaconditionedbytumorcelllinesbaseduponitsabilitytoincreasethepermeabilityofcapillarybloodvessels.ThereportedactivitiesofVEGFincludestimulationofendothelialcellgrowth,angiogenesisandcapillarypermeability.HumanVEGFisa38.2kDahomodimericproteinconsistingoftwo165aminoacidpolypeptidechains.VEGFisexpressedinmanyhumantumorcells,includinghumanadenocarcinoma,humanpancreaticcarcinoma,humanhepatocellularcarcinoma,renalcellcarcinoma,fibrosarcoma,HL60promyelocyticleukemia,GS9LgliomaandU937lymphomacells.Innormaltissues,VEGFexpressionhasbeenobservedinactivatedmacrophages,keratinocytes,hepatocytes,smoothmusclecellsLeydigcells,embryonicfibroblastsandbronchialandchoroidsplexusepithelium,renalglomerularvisceralepitheliumandmesangialcells. |
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