品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
OVERVIEW:
Synonyms | Monoclonal Fascin antibody, Anti-Fascin antibody |
---|---|
Specificity | Human |
Cross Reactivity | To be determined by end-user |
Applications | IHC, WB |
Immunogen | Fascin antibody was raised in mouse using prokaryotic recombinant protein corresponding to the C-terminal region of the fascin molecule as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
---|---|
Clone | IM20 |
Isotype | IgG1 kappa |
Molecular Weight | 55-58 kDa (predicted detection band MW) |
Form & Buffer | Lyophilized tissue culture supernatant containing 15mM NaN3. Reconstitute with 1 ml of sterile distilled water. |
STORAGE & SAFETY:
Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
---|---|
Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
Usage Assay Information:
Usage Recommendations | IHC: 1:200-1:400, WB: 1:100-1:200 |
---|
GENERAL INFORMATION:
Biological Significance | Human fascin is an actin-bundling protein, whose actin binding ability is regulated by phosphorylation. In normal tissues the detection of fascin is reported to be predominantly restricted to dendritic cells and in the thymus has been observed only in medullary dendritic cells. However, in cases of Hodgkin's disease, including nodular sclerosis, mixed cellularity lymphocyte depletion and unclassified cases, most or all Reed Sternberg cells are reported to be positive for fascin. Fascin expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases. |
---|