OVERVIEW:

Synonyms	Monoclonal HIV1 rev antibody, Anti-HIV1 rev antibody, Protein rev antibody, art/trs antibody, Human immunodeficiency virus 1 rev antibody, Anti repression transactivator protein antibody, HIV rev-1, HIV rev 1, Regulator of expression of viral proteins antibody, HIV rev-1 antibody, HIV1 rev, HIV1gp6 antibody, Rev antibody, HIV rev 1 antibody
Specificity	HIV-1 Rev
Cross Reactivity	To be determined by end-user
Applications	ELISA, WB
Immunogen	HIV1 rev antibody was raised in mouse using full length recombinant rev (HIV-1) produced in E.coli expression system as the immunogen.

SPECIFICATIONS:

Host	Mouse
Clone	RMAb6
Isotype	IgG1
Purity	> 95% pure
Form & Buffer	Supplied lyophilized from PBS buffer, with no preservatives added, reconstitute in sterile distilled water.

STORAGE & SAFETY:

Storage	Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations	ELISA: 1:1,000, WB: 1:500

GENERAL INFORMATION:

Biological Significance

Rev is a HIV gene. The gene's protein product allows fragments of HIV mRNA that contain a Rev Response Element (RRE) to be exported from the nucleus to the cytoplasm. In the absence of the rev gene, the host RNA splicing machinery in the nucleus quickly splices the RNA so that only the smaller, regulatory proteins can be produced; in the presence of rev, RNA is exported from the nucleus before it can be spliced, so that the structural proteins and RNA genome can be produced.

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