OVERVIEW:

Synonyms	Monoclonal HIV1 Nef antibody, Anti-HIV1 Nef antibody, HIV1 nef, HIV-1 Nef antibody, HIV nef 1 antibody, 3'ORF antibody, Negative factor antibody, Nef antibody, ABIN1 antibody, HIV nef 1, HIV nef -1, C terminal core protein antibody, ABIN antibody, VAN antibody , p27 antibody, HIV nef -1 antibody, F protein antibody
Specificity	HIV-1 nef
Cross Reactivity	To be determined by end-user
Applications	ELISA, WB
Immunogen	HIV1 Nef antibody was raised in mouse using full length nef (HIV-1, ELI) as the immunogen.

SPECIFICATIONS:

Host	Mouse
Clone	3F2
Isotype	IgG1
Purity	> 95% pure
Form & Buffer	Supplied lyophilized from PBS buffer, with no preservatives added, reconstitute in sterile distilled water.

STORAGE & SAFETY:

Storage	Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations	ELISA: 1:1,000, WB: 1:1,000

GENERAL INFORMATION:

Biological Significance

Nef (Negative Regulatory Factor) is a protein expressed by primate lentiviruses. These include human immunodeficiency viruses (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV). Nef is one of many pathogen-expressed proteins, known as virulence factors, which function to manipulate the host's cellular machinery and thus allow infection, survival or replication of the pathogen. Nef stands for "Negative Factor".

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