JIB-04 (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
JIB-04 is a novel specific inhibitor of the Jumonji family of histonedemethylases in vitro, in cancercells and in tumors in vivo. IC50 = 230,340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 andJMJD2C respectively. Reduces tumor burden and prolongs life in amouse model. Suppresses translation initiation and enhances mTOR inhibitorsensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cellsand crosses the blood brain barrier.
Physical Properties:Yellow powder
MW=308.8 C17H13ClN4
Analysis: >98% (TLC); NMR(Conforms)
Solubilization: May be dissolved inDMSO (30 mg/ml)
Storage: Store desiccated assupplied at -20°C temperature for up to2 years. Store solutions at -20°C for up to two months.
Amount: 5 mg
