5-Fluoro-2’-deoxycytidine;FCDR; FdCyd; NSC-48006; Ro 5-1090
2'-Deoxy-5-Fluorocytidine DNAmethyltransferase inhibitor currently in clinical trials for breast cancer and other solidtumors. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is apyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferationin colon cancer-derived HCT116 cells by activating DNA response pathways. It inhibits variousstrains of pathogenic avian influenza viruses in vitro and in vivo.Physical Properties: White solid; MP= 196oC
MW=245.2 C9H12FN3O4
Analysis: >98% (TLC); NMR(Conforms)
Solubilization: May be dissolved in DMSO (20 mg/ml)
Storage: Store desiccated assupplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
Amount: 50mg