SirtAct
2-?Amino-?N-?cyclopentyl-?1-?(3-?methoxypropyl)-?1H-?pyrrolo[2,?3-?b]quinoxaline-?3-?carboxamide;CAY10591
SirtAct is a Sirt1 activator (233% at 10 mM using the BIOMOL Fluor-de-Lys assay)1 Suppresses TNFa release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells.SIRT1 stimulation by SirtAct leads to decreased tissue factor mediatedthrombogenicity in mice. Inhibits NFkB activation and reduces inflammatory cytokine production in laminapropria mononuclear cells from IBD patients3. Prevents and curesexperimental colitis in a mouse model.
Physical Properties: Olive green powder
MW=367.4 C20H25N5O2
Analysis: 98% (TLC); NMR (Conforms)
Solubilization: May be dissolved in DMSO (50 mg/ml); or ethanol (20 mg/ml,warm)
Storage: Store desiccated assupplied at -20°C for up to 2 years. Store solutions at-20°C for up to 3 months.
Amount: 5mg
