Sirtinol

2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

SirtinolisaselectivesirtuininhibitorwhichdoesnoteffectHDAC1,IC₅₀=131,38and68mMforSIRT1,SIRT2andSir2Prespectively.InducesapoptoticandautophagiccelldeathinMCF-7humanbreastcancercells.SuppressessurvivinexpressionwhichcorrelateswithdecreasedviABIlityinHT29coloncancercells.Displayspro-inflammatoryeffectsinADIpocytes.

PhysicalProperties:Yellowpowder

MW=394.5C₂₆H₂₂N₂O₂

Analysis:>98%(TLC);NMRconforms

Solubilization:MaybedissolvedinDMSO(35mg/ml)orethanol(10mg/ml)

Storage:Storedesiccatedassuppliedat-20°Cforupto2years.Storesolutionsat-20°Cforupto1month.

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