Trans (±)-2-phenylcyclopropanamine;2-PCPA
Tranylcypromine hemisulfate is a irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50< 2 mM1,2.Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in globalincrease of H3K4 methylation along with transcriptional derepression of twoBHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces thegeneration of human-induced pluripotent stem cells in the absence of exogenousSox23. Reduces proliferation,cell cycle progression and invasiveness of endometriotic stromal cells4.Upregulates CD86 expression in THP1 cells5. Cell permeable andactive in vivo.
Physical Properties: White powder
MW=182.2 C9H11N• 1/2 H2SO4
Analysis: >98% (TLC); NMR(conforms)
Solubilization: May be dissolved in water (25 mg/ml)
Storage: Store desiccated assupplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 1 month.
Amount: 50mg
