DMOGN-(2-Methoxy-2-oxoacetyl)glycinemethyl ester; DimethyloxalylglycineDMOG inhibits PHD or prolyl hydroxylase domain-containing proteins, activatingHIF1a and inhibiting JMJD2A (IC50 = 2.5 mM). Displaysneuroprotective effects. Inhibits neuronal cell death caused by neurotrophindeprivation. Prevents activation of the ATR/CHK1/p53 pathway andsuppresses apoptosis induced by DNA damage.Physical Properties: White tooff-white solid; MP=46-48°CMW=175.1 C6H9NO5
Analysis: >98% (TLC); NMR(Conforms)
Solubilization: May be dissolved in DMSO (30 mg/ml), ethanol (25 mg/ml),or water (30 mg/ml)
Storage: Store desiccated assupplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
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