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商品描述
IOX1 .jpg)
8-Hydroxy-5-quinolinecarboxylic acid;(5-Carboxy-8HQ)
IOX1 inhibitsthe JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 =0.12, 0.07, 0.2, 0.3, 0.6, and 1 mM for JMJD3, JMJD1A,JMJD2A, JMJD2E, JMJD2C and UTX respectively1. A broad spectrum2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling1.Cell permeablePhysical Properties: Yellow powder
MW=189.2 C10H7NO3
Analysis: >98% (HPLC); NMR(Conforms)
Solubilization: May be dissolved in DMSO (20 mg/ml)
Storage: Store desiccated assupplied at ambient temperature for up to 1 year. Store solutions at -20°C forup to 3 months.