N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-ß-alanineethyl ester
GSK-J4 is a histone demethylaseJMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. ReducesLPS-induced proinflammatory cytokine production in primary human macrophages(IC50 = 9 µMfor the inhibition of TNFarelease). Cell permeable, ethyl ester of GSK-J1. Rescues newbornpups from embryonic lethality in BRAF knockin mice which recapitulatemajor features of RASopathies. Inhibits the growth of T-cell acute lymphoblasticleukemia (T-ALL) cells.
Physical Properties: Yellow wax
MW=417.5 C24H27N5O2
Analysis: >99% (TLC); NMR(Conforms)
Solubilization: May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)
Storage: Store, as supplied, at -20°C. Store solutions at -20°C for up to3 months.
Amount: 5mg
