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商品描述
Tubastatin A
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Tubastatin A is a potent and selective histone deacetylase 6 (HDAC6)inhibitor, IC50=15 nM (>1000-fold selective against other HDACsand 60-fold for HDAC8). InhibitsTNFa (IC50=272 nM) and IL-6 (IC50=712nM) in LPS-stimulated human macrophages and displays anti-inflammatory activityin animal models. Improves survival in animal models of sepsis.Improves cognition in Alzheimers disease transgenic mice. Cellpermeable.
Physical Properties: white powderMW=371.9 C20H21N3O2 ·HCl
Analysis: 99% (HPLC); NMR conforms
Solubilization: May be dissolved in DMSO (50mg/ml)
Storage:Store as supplied at -20°C for up to 2 years. Store solutions at -20°Cfor up to 3 months.
Amount: 1mg
