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商品描述
RomidepsinFK228;orFR901228;orDepsipeptide
FK228;orFR901228;orDepsipeptide
RomidepsinisapotentandselectiveinhibitorofclassIhistonedeacetylases(HDACs),IC50=36,47,510and14,000nMforHDAC1,2,4andHDAC6,respectively1.Inducesapoptosisinavarietyofcelllines2anddisplaysantitumoractivityinmousemodels3.RecentlyapprovedforclinicaluseinT-celllymphoma4.