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商品描述
CUDC-101 
Reaction Biology常用产品报价单产品名货号公司分类商城分类美金价Reaction Biology/ASH1L (His) Methyltransferase/HMT-11-376HMT-11-376Biochemical Assay Services反应底物375.00Reaction Biology/Core Histones (Chicken)/HMT-35-435HMT-35-435Biochemical Assay Services抗鸡290.00Reaction Biology/BromoMELT Assay Kit/BRD-Kit-01BRD-Kit-01Cell AssaysRACE试剂盒920.00Reaction Biology/NDS2 Protein/HMT-21-122HMT-21-122Electrophysiology Assays蛋白纯化试剂盒635.00Reaction Biology/NSD2 (His) Methyltransferase Protein/HMT-21-138HMT-21-138Electrophysiology Assays细胞因子520.00Reaction Biology/MPP8-[CHR] (His) {M-phase phosphoprotein 8-[CHR] (His)}/RD-11-462RD-11-462Electrophysiology Assays血清纯化蛋白320.00Reaction Biology/PRMT5 Methyltransferase Protein - Buy Online Now/HMT-22-148HMT-22-148Electrophysiology Assays生长因子925.00 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
CUDC-101 is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. Itis a potent HDAC inhibitor which also inhibits EGFR and HER2, IC50 = 4.4, 2.4 and 15.7 nMrespectively. It not only blocks EGFR and HER2 but also attenuatesmultiple compensatory pathways such as AKT, HER3 and MET which enable tumorcells to escape the effects of conventional EGFR/HER2 inhibitorsPhysical Properties: White to off-whitepowderMW = 434.5 C24H26N4O4
Analysis: >99% (HPLC); NMR(Conforms); MP=188-190oC
Solubilization: May be dissolved in DMSO (25 mg/ml)
Storage: Store desiccated assupplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
Amount: 5mg
