Panobinostat (E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide;
LBH-589
Panobinostat is a potent inhibitor of class I and II HDACs1. Cotreatment withpanobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BCand AML cells2. A potent antimyeloma agent that overcomes drugresistance3.
Physical Properties: Off-whitepowder
MW=349.4 C21H23N3O2
Analysis: >98% (HPLC);NMR (Conforms)
Solubilization: May be dissolved in DMSO (100 mg/ml); or ethanol (5 mg/ml,warm)
Storage: Store desiccated assupplied at -20°C for up to 1 year. Store solutions at -20°C for up to onemonth.
Amount: 5mg
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