Pyridin-3-ylmethyl4-((2-aminophenyl)carbamoyl)benzylcarbamate; Entinostat
MS-275 is a potent and selective non-hydroxamate HDAC inhibitor. Considered to be a class Iselective inhibitor but displays some selectivity amongst class I members: HDAC1 (IC50 = 0.3 mM); HDAC3 (IC50 = 8 mM) with no inhibition of HDAC8 (at>100 mM)1. Induceshyperacetylation of nuclear histones in tumor cells resulting in inhibition ofproliferation of a variety of human tumor cell lines2. Protects p53-deficient mice against ischemic injury3.Supresses the p38 MAP kinase pathway in rheumatoid arthritic synovialfibroblasts4. Active in vivo.
Physical Properties: Pale yellowpowder
MW=376.4 C21H20N4O3
Analysis: >98% (TLC); NMR(Conforms)
Solubilization: May be dissolved in DMSO (25 mg/ml, warm)
Storage: Store desiccated assupplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 week.
Amount: 5mg