DESCRIPTION:HumanrecombinantUHRF1SRAdomainexpressedasanN-terminalGSTfusionproteininE-coli.Atumorpromoteroverexpressedinawidevarietyofcancers,theepigeneticregulatorUHRF1isamultidomainproteinthatco-localizeswithDNMT1andfunctionsinthemaintenanceofDNAmethylationpatterns.ItsSRAdomainisanepigeneticreaderthatspecificallybinds5-methylcytosineathemimethylatedCpGsites.
ACCESSION#:NM_001048201
UniprotLink
INCLUDESAMINOACIDS:414-617
TAG(S):N-terminalGSTtag
MW:49.7kDa
EXPRESSIONSYSTEM:E.coli
SUPPLIEDAS:Solutionofpurifiedrecombinantproteinin50mMTrisHCl,pH7.5,500mMNaCl,1mMTCEP,10%glycerol(v/v)
STORAGE:-70°C.Thawquicklyandstoreonicebeforeuse.Theremaining,unused,undilutedproteinshouldbesnapfrozen,forexampleinadry/iceethanolbathorliquidnitrogen.Minimizefreeze/thawsifpossIBLe,butverylowvolumealiquots(<5µl)orstorageofdilutedproteinisnotrecommended.
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SubstantialDiscountsAvailableonBulkQuantities
