DESCRIPTION:Alongwithitsclosehomolog,SUV39H1,SUV39H2isresponsIBLeforthetranscriptionallyrepressivemodification,H3K9me3,inheterochromatin.MicedeletedinbothSUV39H2andSUV39H1haveelongatedtelomeres,implyingarolefortheseenzymesandH3K9methylationinregulationoftelomerelength.PolymorphismsinthehumanSUV39H2genehavebeenassociatedwithcomplicationsoftypeIdiabetesandlungcancerrisk.
ACCESSION#:NM_001193424
UniprotLink
INCLUDESAMINOACIDS:46-410(C-term.)
TAG(S):N-terminalfusionproteinwithaC-terminalHis-tag
MW:98.8kDa
EXPRESSIONSYSTEM:E.coli
SUPPLIEDAS:Solutionofpurifiedrecombinantproteinin50mMTris/HCl,pH7.5,500mMNaCl,20%glycerol,1mMTCEP
STORAGE:-80°C,aliquotandsnap-freezeafterfirstuse.
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