DESCRIPTION:Afive-membercomplex(EZH2,AEBP2,EED,RbAp48,SUZ12)inwhichthecatalyticsubunit(EZH2)actsasahistoneH3lysine-27methyltransferase,generatingtrimethylatedhistoneH3lysine-27(H3K27me3),anepigeneticmarkessentialforprogrammedrepressionofgeneexpression.EZH2isoverexpressedinawiderangeofhumancancersandisconsideredapromisingtargetforthedevelopmentofanti-cancertherapies.
ACCESSION#:NM_001203247,NM_001114176,NM_003797,NM_005610,NM_015355
UniprotLink
INCLUDESAMINOACIDS:EZH22-746,AEBP22-517,EED2-441,RbAp482-425,SUZ122-739;Allfull-length
TAG(S):N-terminalFlag-tagonEED,allothersN-terminalHis-tag
MW:333.8kDa
EXPRESSIONSYSTEM:Insectcell/Baculovirus
SUPPLIEDAS:Solutionofpurifiedrecombinantproteinsin20mMTris-HCl,pH7.9,150mMNaCl,2mMMgCl2,2mMDTT,20%glycerol(w/v),0.01%NP-40
STORAGE:-80°C,aliquotandsnap-freezeafterfirstuse.
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