DESCRIPTION:HumanDOT1L,anditshomologsinotherspecies,areuniqueamongthehistonelysinemethyltransferasesinnotcontainingaSETdomainandintargetingaspecificresidueinthehistoneH3globulardomain(lysine-79;H3K79).
InappropriaterecruitmentofDOT1LbyMLL-fusionproteinsisimplicatedinthedevelopmentofleukemias.
ACCESSION#:NM_032482
UniprotLink
INCLUDESAMINOACIDS:1-416
TAG(S):N-terminalGST
MW:80.0kDa
EXPRESSIONSYSTEM:E.coli
SUPPLIEDAS:Solutionofpurifiedrecombinantproteinin25mMTris-HCl,pH7.5,100mMNaCl,0.05%Tween20,3mMDTT,20%(v/v)glycerol.
STORAGE:-80°C,aliquotandsnap-freezeafterfirstuse.
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