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4000-520-616 / 18915418616
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商品描述
| ProductDetails | |
|---|---|
| Synonyms | DecoyReceptor3;TumorNecrosisFactorReceptorSuperfamilyMember6B;TNFRSF6B;M68 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanDcR3(aa24-300)isfusedtotheN-terminusoftheFcregionofhumanIgG1. |
| Crossreactivity | Human |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitutewith100µlsterilewater. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceO95407:DcR3(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Decoyreceptor3(DcR3;TNFRSF6B;M68)isamemberoftheTNFreceptorsuperfamily.DcR3sharessequenceidentitywithOPG(31%),TNF-RII(29%)andFas(17%)andisexpressedinavarietyofdifferenttissuesandathighlevelsinmanymalignanttumors.LigandsofDcR3includeFasligand,homologoustolymphotoxinshowinginducIBLeexpressionandcompetingwithHSVglycoproteinDforherpesvirusentrymediator(areceptorexpressedbyTlymphocytes),TNF-likemolecule1Aandheparansulfateproteoglycans.DcR3modulatesthefunctionofTcells,dendriticcellsandmacrophages.DcR3/FcfusionproteinscanbindtohumanandmouseBcellsandsuppresstheactivationofBcells.
