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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinC-terminalHydrolaseCYLD;DeubiquitinatingEnzymeCYLD;UbiquitinThioesteraseCYLD;Ubiquitin-specific-processingProteaseCYLD;CYLD1 |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | HumanCYLDIsoform1(AccessionNr.Q9NQC7-1)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaClandDTT. |
| OtherProductData | Use:Ubiquitin-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-500nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitincarboxyl-terminalhydrolaseCYLDisa956aminoacid(aa)memberofthepeptidaseC67proteinfamilywithapredictedmolecularweightof107kDa.ThemouseandratCYLDorthologsshare95%and94%aasequenceidentitywiththehumanprotein,respectively.TwoisoformsofCYLDhavebeenidentified,afull-lengthisoformandasecondisoformthatlacksaa305-307duetoalternativesplicing.ExpressionofCYLDhasbeenreportedinfetalbrainaswellasadultbrain,heart,leukocytes,skeletalmuscle,spleenandtestis.CYLDactsasadeubiquitinaseandremovesK63-linkedubiquitinchainsfrommultiplesubstratesincludingIκB,c-Jun,andc-Fos,resultingintheinhibitionofNF-κBandJNKsignaling.Insomecontexts,CYLDenhancesmitosisentryandithasalsobeenshowntodelayG1/SphaseentrysuggestingthatCYLDregulatesmultiplephasesofthecellcycle.CYLDisrecognizedasatumorsuppressorandmutationsinCYLDresultinskinappendagesyndromesincludingBrooke-SpiegleSyndrome,familialcylindromatosisandfamilialtrichoepitheliomastype1.
