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蚂蚁淘在线 / 品牌中心 / Adipogen / Adipogen/20S Proteasome Activation Solution (100X)/AG-10T-0010-R100/100 µl
商品描述
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formulation | Liquid.3%SDS. |
| Crossreactivity | Multi-species |
| Declaration | ManufacturedbyBostonBiochem |
| OtherProductData | Use:Thisbuffercontainstheoptimalformulationfortheactivationofallisoformsofconstitutive20Sandimmuno20Sproteasomeenzymesincludinghuman,rabbit,rat,andmouse.Diluteto1Xforactivationforafinalconcentrationof0.03%inassay.Diluteinreactionbufferspriortoaddingproteasome(donotadddirectlytosolutionsalreadycontainingproteasome).Usewithpeptidesubstratescontainingarginineresiduesisnotrecommended,asprecipitationofthesubstratemayoccur.Intheseinstancesnon-chemicalactivationmayprovidebetterresults. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
The20SProteasomeisthecatalyticcorecomponentofthemulti-complex26SProteasomethatselectivelydegradesintracellularproteins.Itiscommonlyassociatedwithregulatorycomplexes,whichincludethe19SProteasome,thePA28α/βcomplex,orthePA28γcomplex.The20SProteasomeiscomposedof28subunitsarrangedintofourstackedrings.Theouterrings,containingsevensubunitseach,arecomposedofclosely-relatedbutnon-identicalαsubunits.Theamino-terminaltailsoftheαsubunitsformagatethatrestrictssubstrateentryintothecatalyticcore.Theinnerrings,alsocontainingsevensubunitseach,arecomposedofclosely-relatedbutnon-identicalβsubunits.Theamino-terminaltailsofsixoftheβsubunits,threeperring,haveproteolyticactivity.Inhibitionof20SProteasomeproteolyticcoreactivityusingsmallmoleculeinhibitorsisavaluabletoolforthefunctionalstudyofavarietyofproteinsandfortherapeuticintervention.The20SProteasomecanbeactivatedchemicallybytheadditionofdetergentorbytheproteinaceousactivatorPA28Activatorα.
