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蚂蚁淘在线 / 品牌中心 / Adipogen / Adipogen/IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-12021R-C100/100 µg
商品描述
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-21Receptor;CD360;NILR |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofmouseIL-21R(aa20-234)isfusedtotheN-terminusoftheFcregionofamutantmouseIgG2a. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | ShowsthebiologicalfunctionoftheIL-21Rmoietyandexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | Non-lytic:Actsasalonglastingfusionproteinwhichonlybindstothereceptor.Mutationstothecomplement(C1q)andFcgRIbindingsitesoftheIgGsFcfragmentrenderthefusionproteinsincapableofantibodydirectedcytotoxicity(ADCC)andcomplementdirectedcytotoxicity(CDC). NCBIreferenceAAL82636.1:IL-21R(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-21receptor(IL-21R)isatypeItransmembraneglycoproteinwithintheclassIcytokinereceptorfamily,type4subfamily.ComplexformationbetweenIL-21Randthecommonγchain(γc)isrequiredforsignaling.IL-21RisexpressedmainlyonBcells(highestonmature,activated,follicularandgerminalcenterBcells),NKcellsandactivatedTcells,butisalsofoundondendriticcells,alternativelyactivatedmacrophages,intestinallaminapropriafibroblastsandepithelialcellsandkeratinocytes.BcellIL-21RengagementinducesBlimp1(whichmediatesplasmacelldifferentiation)andisimportantformemoryresponses.IL-21RengagementonmouseNKcellsenhancestheircytotoxicactivityandIFN-γproduction.IL-21RengagementonCD8+Tcellsaidscontrolofviralinfectionandtumorgrowth;IL-21RisalsonecessaryforsufficientnumbersofregulatoryTcellstocombatchronicinflammation.IL-21Rexpressionisoftenupregulatedinallergicskininflammation,systemiclupuserythematosusanddiffuselargeBcelllymphoma(DLBCL).
