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商品描述
| ProductDetails | |
|---|---|
| Synonyms | FliC(TLR5Mutant) |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Thenativeflagellin[FliC]fromSalmonellaentericaSEROvarTyphimuriumstrainATCC14028(aa1-495)containsasubstitutionofaminoacids90-97requiredforTLR5signalingbyamotiffromanon-signalingflagellinandisfusedattheN-terminustoaHis-tag. |
| Crossreactivity | Human Mouse |
| Specificity | NotdetectedbyhumanandmouseTLR5(Toll-likereceptor5). |
| BIOLOGicalActivity | DoesnotactivateTLR5inhumanepithelialcellassaysbasedonNF-κBluciferasefusions,invivoonexpressionofCCL20orIL-6.ItcanbeusedasnegativecontrolforTLR5signalingassays. |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | NCBIlinkNP_460912.1:Flagellin[Salmonellaentericasubsp.entericaserovarTyphimuriumstr.LT2] |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Flagellinisthesubunitproteinwhichpolymerizestoformthefilamentsofbacterialflagella.ItactivatestheinnateimmunesystemthroughthereceptorToll-likeReceptor5(TLR5)ortheintracellularNLRC4protein.TheFlagellin(TLR5Mutant)(rec.)cannotbedetectedbyhumanandmouseTLR5.IthasnotbeentestedonNLRC4.
