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商品描述
| ProductDetails | |
|---|---|
| Synonyms | PGE2;Dinoprostone;9-Oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oicacid;ProstinE2;Prepidil;NSC165560;11α,15α-Dihydroxy-9-oxo-5-cis,13-trans-prostADIenoicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C20H32O5 |
| MW | 352.5 |
| MerckIndex | 14:7877 |
| CAS | 363-24-6 |
| RTECS | UK8000000 |
| Source/HostChemicals | Synthetic(originallyisolatedfromsheepprostate). |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | Solubleinethanol(50mg/ml),DMSO(50mg/ml)orDMF(100mg/ml).SparinglysolubleinPBS,pH7.2(5mg/ml). |
| Crossreactivity | Multi-species |
| OtherProductData | DonotaddPGE2tobasicsolutionwithpH>7.4. |
| InChiKey | XEYBRNLFEZDVAW-ARSRFYASSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Oneofthemosttypicallipidmediatorsproducedfromarachidonicacid(AA)bycyclooxygenase(COX)astherate-limitingenzymeandactsonfourkindsofreceptorsubtypes(EP1,EP2,EP3andEP4)withhighbindingaffinity(Kdvaluesrangebetween~1-10nM).
- Regulatorofnumerousphysiologicalfunctionsrangingfromreproductiontoneuronal,metabolicandimmunefunctions.
- Impliedintheregulationofbodytemperatureandsleep-wakeactivity.Regulatingfactorforboneformationandbonehealing.Potentvasodilator.Influencessmoothmusclerelaxation,fertilityandgastricmucosalintegrity(firstlineofdefenseoftheintestinalimmunesystem).
- Actsasapro-inflammatorymediator,butalsoexertsanti-inflammatoryresponses.Aspro-inflammatorymediator,PGE2contributestotheregulationofthecytokineexpressionprofileofDCsandhasbeenreportedtobiasTcelldifferentiationtowardsaThelper(Th)1orTh2response.Exertsanti-inflammatoryactionsoninnateimmunecellslikeneutrophils,monocytesandNKcells.
- ImplicatedinvarioustumOrigenicprocesses.FacilitatestumorprogressionthroughstimulationofangiogenesisviaEP2,mediatescellinvasionandmetastasisformationviaEP4andpromotescellsurvivalbyinhibitingapoptosisvianumeroussignalingpathways.Tumorcell-producedPGE2hasbeenimplicatedinstrategiesoftumorsforevasionofimmunesurveillance.FurThermore,itcanenhancetheinhibitoryfunctionofhumanregulatoryTcells.
- Regulatesvertebratehematopoieticstemcell(HSC)homeostasis.
- InhibitsNLRP3byactingthroughreceptorEP4activationthatincreasescAMP.cAMPactivatesPKAthatphosphorylatesNLRP3atserine295.PKAphosphorylationofNLRP3inhibitstheNLRP3ATPaseactivity,whichisrequiredforassemblyofNLRP3-ASCcomplexes.
ProductReferences
Adipogen科学研究的可重复性已成为一个主要问题，导致学术界和药物研究界对科学结果缺乏信任。正在进行的关于结果可重复性的对话包括未经正确验证的研究试剂（例如抗体）的作用。抗体是生命科学中的宝贵工具，已成为基础研究的重要工具。它们对独特的蛋白质靶标的高特异性和选择性使其成为必不可少的研究试剂。然而，尽管抗体被设计为识别靶蛋白，但它们可能无法在所有应用中都能够识别（例如那些改变靶蛋白结构的抗体）。在过去的几年中，为仅研究用（RUO）领域贡献商业抗体的抗体供应商的数量一直在稳定增长，其中用于确认敏感性，特异性，反应性和批次间一致性的验证数据不一致。 因此，由国际科学家委员会以及来自学术和行业实验室的领导人，期刊编辑和包括Adipogen Life Sciences在内的商业抗体供应商的领导者提出的许多倡议，提出了抗体验证的广泛指导方针以及详细的取决于环境的措施随后应由抗体供应商提供 - ProstaglandinE2atnewglance:novelinsightsinfunctionaldiversityoffertherapeuticchances:D.F.Legler,etal.;Int.J.Biochem.CellBiol.42,198(2010)(Review)
- ProstaglandinE2,animmunoactivator:D.Sakata,etal.;J.Pharmacol.Sci.112,1(2010)(Review)
- NewlyemergingrolesforprostaglandinE2regulationofhematopoiesisandhematopoieticstemcellengraftment:E.M.Durand,etal.;Curr.Opin.Hematol.17,308(2010)(Review)
- Prostanoidsignaling:dualroleforprostaglandinE2inneurotoxicity:D.Milatovic,etal.;Neurotoxicol.32,312(2011)(Review)
- ProstaglandinE2EPreceptorsastherapeutictargetsinbreastcancer:J.Reader,etal.;CancerMetastasisRev.30,449(2011)(Review)
- ProstaglandinE2andTcells:friendsorfoes?V.Sreeramkumar,etal.;Immunol.CellBiol.90,579(2012)(Review)
- RegulationofimmuneresponsesbyprostaglandinE2:P.Kalinski;J.Immunol.188,21(2012)(Review)
- PolarizationoftheinnateimmuneresponsebyprostaglandinE2:apuzzleofreceptorsandsignals:M.Rodriguez,etal.;Mol.Pharmacol.85,187(2014)(Review)
- ProstaglandinE2-inducedinflammation:RelevanceofprostaglandinEreceptors:K.Kawahara,etal.;Biochim.BiophysActa.1851,414(2015)(Review)
- ProstaglandinE2andtheEPreceptorsinmalignancy:possIBLetherapeutictargets?G.O"Callaghan&A.Houston;Br.J.Pharmacol.172,5239(2015)(Review)
- ProstaglandinE2InhibitsNLRP3InflammasomeActivationthroughEP4ReceptorandIntracellularCyclicAMPinHumanMacrophages:M.Sokolowska,etal.;J.Immunol.194,5472(2015)
- NLRP3inflammasomeinhibitionisdisruptedinagroupofauto-inflammatorydiseaseCAPSmutations:L.Mortimer,etal.;Nat.Immunol.(Epubaheadofprint)(2016)
