| ProductDetails | |
|---|---|
| Synonyms | Proepithelin;PEPI;PCCell-derivedGrowthFactor |
| ProductType | Kit |
| Properties | |
| ApplicationSet | QuantitativeELISA |
| Specificity | Detectsmouseprogranulin.Doesnotcross-reactwithhumanprogranulin. |
| Crossreactivity | Mouse |
| Quantity | 1x96wells 2x96wells(TwinPlex) |
| Sensitivity | 60pg/ml |
| Range | 0.125to8ng/ml |
| SampleType | CellCultureSupernatant Serum |
| AssayType | Sandwich |
| DetectionType | Colorimetric |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Afterstandardreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. Plateandreagentsshouldreachroomtemperaturebeforeuse. |
| Use/StABIlity | 12monthsafterthedayofmanufacturing.SeeexpirydateonELISAKitbox. |
| Documents | |
| Manual |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Progranulin(PGRN)isawidelyexpressedpluripotentgrowthfactorwhichplaysaroleinprocessessuchasdevelopment,woundrepairandinflammationbyactivatingsignalingcascadesthatcontrolcellcycleprogressionandcellmotility.Itsfunctioninthecentralnervoussystemisofinterest,asmutationsinthePGRNgenewerefoundincasesoffrontotemporaldegeneration(FTLD).Inaddition,PGRNhasalsobeenlinkedtotumOrigenesis.Newcutting-edgepublicationshaveshownthatprogranulinmightbeabioMarkernotonlyforFTLD,butalsoforothertypesofAlzheimer‘sdisease(AD).ThisnewdataevensupposesthepotentialofprogranulintobeabiomarkerforMCI(MildCognitiveImpairment),whichwouldbeahallmarkinADresearch.Additionally,PGRNisdescribedasanewligandofTNFreceptorsandapotentialtherapeuticagainstinflammatorydiseaselikearthritis.
- Microglialupregulationofprogranulinasamarkerofmotorneurondegeneration:T.Philips,etal.;J.Neuropathol.Exp.Neurol.69,1191(2010)
- ProgranulinenhancesneuralProgenitorcellproliferationthroughglycogensynthasekinase3βphosphorylation:T.Nedachi,etal.;Neuroscience185,106(2011)
- Thefrontotemporallobardegenerationriskfactor,TMEM106B,regulateslysosomalmorphologyandfunction:O.A.Brady,etal.;Hum.Mol.Genet.22,685(2013)
- Dissociationoffrontotemporaldementia-relateddeficitsandneuroinflammationinprogranulinhaploinsufficientmice:A.J.Filiano,etal.;J.Neurosci.33,5352(2013)
- Progranulinandafivetransmembranedomain-containingreceptor-likegenearethekeycomponentsinreceptoractivatorofnuclearfactorB(RANK)-dependentformationofmultinucleatedosteoclasts:J.Oh,etal.;J.Biol.Chem.290,2042(2015)
- Effectsofexerciseonprogranulinlevelsandgliosisinprogranulin-insufficientmice:A.E.Arrant,etal.;eNeuro2,e0061-14.2015(2015)
- TrehaloseupregulatesprogranulinexpressioninhumanandmousemodelsofGRNhaploinsufficiency:anoveltherapeuticleadtotreatfrontotemporaldementia:C.J.Holler,etal.;Mol.Neurodegener.11,46(2016)
- Progranulindeficiencyleadstosevereinflammation,lunginjuryandcelldeathinamousemodelofendotoxicshock:Y.Yu,etal.;J.cellMol.Med.20,506(2016)
- Progranulinregulateslysosomalfunctionandbiogenesisthroughacidificationoflysosomes:Y.Tanaka,etal.;Hum.Mol.Genet.(Epubaheadofprint)2017
- ProgranulinGeneTherapyImprovesLysosomalDysfunctionandMicroglialPathologyAssociatedwithFrontotemporalDementiaandNeuronalCeroidLipofuscinosis:A.E.Arrant,etal.;J.Neurosci.,aheadofprint(2018)
