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4000-520-616 / 18915418616
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0512-67156496
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商品描述
| Product Details | |
|---|---|
| Synonyms | Splitomycin; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1-Naphthalen propanoic acid |
| Product Type | Chemical |
| Properties | |
| Formula | C13H10O2 |
| MW | 198.2 |
| CAS | 5690-03-9 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in methanol, ethanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| Other Product Data | Handling Note: After reconstitution use immediately due to decomposition. We recommend to use fresh solutions. If you prepare aliquots store immediately at -20°C. |
| InChi Key | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Keep cool and dry. Keep under inert gas. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4].
- Displays higher activity in vivo than in vitro [1-4].
- Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5].
- Shown to have diverse effects also in mammalian cells [6-10].
Product References
Adipogen科学研究的可重复性已成为一个主要问题，导致学术界和药物研究界对科学结果缺乏信任。正在进行的关于结果可重复性的对话包括未经正确验证的研究试剂（例如抗体）的作用。抗体是生命科学中的宝贵工具，已成为基础研究的重要工具。它们对独特的蛋白质靶标的高特异性和选择性使其成为必不可少的研究试剂。然而，尽管抗体被设计为识别靶蛋白，但它们可能无法在所有应用中都能够识别（例如那些改变靶蛋白结构的抗体）。在过去的几年中，为仅研究用（RUO）领域贡献商业抗体的抗体供应商的数量一直在稳定增长，其中用于确认敏感性，特异性，反应性和批次间一致性的验证数据不一致。 因此，由国际科学家委员会以及来自学术和行业实验室的领导人，期刊编辑和包括Adipogen Life Sciences在内的商业抗体供应商的领导者提出的许多倡议，提出了抗体验证的广泛指导方针以及详细的取决于环境的措施随后应由抗体供应商提供 - Identification of a small molecule inhibitor of Sir2p: A. Bedalov, et al.; PNAS 98, 15113 (2001)
- Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast: M. Hirao, et al.; J. Biol. Chem. 278, 52773 (2003)
- Inhibitors of Sir2: evaluation of splitomicin analogues: J. Posakony, et al.; J. Med. Chem. 47, 2635 (2004)
- The Sir 2 family of protein deacetylases: J.M. Denu; Curr. Opin. Chem. Biol. 9, 431 (2005) (Review)
- Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53: I.A. Kim, et al.; Clin. Cancer Res. 12, 940 (2006)
- SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome: R. Biacsi, et al.; PLoS Genet. 4, e1000017 (2008)
- Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release: F.C. Liu, et al.; Thromb. Res. 124, 199 (2009)
- Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells: M.R. Kang, et al.; Nucleic Acids Res. 38, 822 (2010)
- Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells: A. Breitenstein, et al.; Cardiovasc. Res. 89, 464 (2011)
- Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival: U.H. Beier, et al.; Mol. Cell Biol. 31, 1022 (2011)
