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商品描述
| Product Details | |
|---|---|
| Synonyms | GQ1b . 4Na; Tetrasialoganglioside GQ1b . 4Na |
| Product Type | Chemical |
| Properties | |
| Formula | C106H178N6O55 . 4Na |
| MW |
2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid) |
| Sequence | Structure: IV3Neu5Ac2II3NeuAc2GgOse4Cer; α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 by vol.; stearic acid over 90% |
| CAS | 68652-37-9 |
| Source/Host Chemicals | Isolated from bovine brain. |
| Purity Chemicals | ≥98% (TLC) |
| Solubility | Soluble in water (micellar aggregates) or chloroform:methanol (2:1). |
| Formulation | Lyophilized. |
| Endotoxin Content | Not detectable. |
| Identity | Determined by 1H-NMR, MS and HPTLC. |
| InChi Key | QISNAVHLOKDTLS-UTKQHEHRSA-J |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GQ1b specifically promotes neural differentiation of human neuroblastoma cells. Anti-GQ1b antibodies are present in serum from Miller-Fisher syndrome patients.
Product References
Adipogen科学研究的可重复性已成为一个主要问题，导致学术界和药物研究界对科学结果缺乏信任。正在进行的关于结果可重复性的对话包括未经正确验证的研究试剂（例如抗体）的作用。抗体是生命科学中的宝贵工具，已成为基础研究的重要工具。它们对独特的蛋白质靶标的高特异性和选择性使其成为必不可少的研究试剂。然而，尽管抗体被设计为识别靶蛋白，但它们可能无法在所有应用中都能够识别（例如那些改变靶蛋白结构的抗体）。在过去的几年中，为仅研究用（RUO）领域贡献商业抗体的抗体供应商的数量一直在稳定增长，其中用于确认敏感性，特异性，反应性和批次间一致性的验证数据不一致。 因此，由国际科学家委员会以及来自学术和行业实验室的领导人，期刊编辑和包括Adipogen Life Sciences在内的商业抗体供应商的领导者提出的许多倡议，提出了抗体验证的广泛指导方针以及详细的取决于环境的措施随后应由抗体供应商提供 - Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
- A novel glycosignaling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation. S. Tsuji, et al.; Neurochem. 21, 549 (1992)
- Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)
- Fisher syndrome: clinical features, immunopathogenesis and management. M. Mori, et al.; Expert Rev. Neurother. 12, 39 (2012)
