Griseofulvin is a fungistatic antifungal that targets microtubules.Isolated from Penicillium griseofulvum, Griseofulvin binds tubulin and interferes with mitosis and nucleic acid synthesis.It is effective against fungi causing tinea such as Microsporum, Epidermophyton, and Trichophyton.It has also been shown to promote apoptosis in in vitro studies of human tumor cell lines.

Griseofulvin is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product SpecificationsGriseofulvin

MOLECULAR BIOLOGY GRADE

Formula: C₁₇H₁₇ClO₆

MW: 352.77 g/mol

Storage/Handling: Store at 4°C.This product is soluble in water (8.6 µg/ml).

PubChem Chemical ID: 441140

★活体技术荧光检测荧光蛋白标记适用于标记细胞、病毒、基因等，通常使用的是 GFP、EGFP、RFP（DsRed）等；荧光染料标记适用于标记抗体、多肽、小分子药物等；常用的有 Cy3、Cy5、Cy5.5 及 Cy7量子点标记（新的标记方法）适用于标记肿瘤，主要应用在活细胞实时动态荧光观察与成像；量子点（quantum dot) 是一种能发射荧光的半导体纳米微晶体，外观恰似一极小的点状物。量子点荧光比有机荧光染料的发射光强的 20 倍，稳定性强 100 倍以上，具有荧光发光光谱较窄、量子产率高、不易漂白、激发光谱宽、颜色可调，并且光化学稳定性高，不易分解等诸多优点。