Ampicillintrihydrate,USPisamemberoftheextendedspectrumβ-lactamfamilyandsimilarinstructuretopenicillin.AmpicillinresistanceisfrequentlyduetosecretionofplasmidencodedESBLs.

TOKU-Eoffersfiveformsofampicillin:

• Ampicillin/sulbactam(2:1)(A071)
• Ampicillinanhydrous(A043)
• Ampicillinsodium(A042)
• Ampicillin,USP(A009)
• Ampicillintrihydrate,EP(A020)

Inaqueoussolution,ampicillinsodiumisfreelysoluble(50mg/mL).Ampicillintrihydrateisslightlysolubleinwater(10mg/mL)andfreelysolublein1NHCl(50mg/mL).Ampicillinanhydrousissparinglysolubleinwaterandfreelysolublein1NNH4OH(50mg/mL).Ampicillinsodiumiscommonlyusedtoselectforsuccessfullytransformedbacteria.Ampicillinanhydrous(powder)isthemoststableandpureformofampicillinTOKU-Eoffers.

CASNumber

7177-48-2

MolecularFormula

C₁₆H₁₉N₃O₄S·3H₂O

MolecularWeight

403.44

MechanismofAction

Likeallβ-lactams,ampicillininterfereswithPBP(penicillinbindingprotein)activityotherwiseinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresidues.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedultimatelyleADIngtocelllysis.

StorageConditions

≤30°C

TariffCode

2941.10.1000

Spectrum

Ampicillin,USPtargetsnon-ESBL(ExtendedSpectrumβ-lactamase)bacteriaincludingStaphylococcusandStreptococcusspeciesandmedicallyimportantentericpathogenssuchasShigellaandSalmonella.Interestingly,ampicillinhasbeenfoundtobeeffectiveagainstcertainβ-lactamsensitiveVREorvancomycinresistantEnterococcus;aglycopeptideantibioticresistant"superbug."ResistancetoampicillinisroutinelyutilizedasaselectableMarkertoconfirmsuccessfulcelltransformation.

Specifications:

TOKU-E植物生物学植物生物学，基因工程，改变植物生长特性。植物生物学是指植物的科学和研究。植物的特性和生长可以通过多种方式进行改变，包括基因工程和各种生长调节剂或激素的使用。可以通过农杆菌介导的转化或其他方法将DNA导入植物，  其中将质粒上的目标基因从农杆菌  细胞中转移  并整合到植物组织中。植物还易受细菌和真菌性植物病原体的侵害，而使用低毒性抗生素  和  抗真菌药可以控制或消除这些病原体  。