Amphotericin B, USP is a polyene antifungal or antimycotic compound derived from Streptomyces nodosus. Amphotericin B is nearly insoluble in water but can be solubilized in sodium deoxycholate.

Amphotericin B, USP meets United States Pharmacopoeia specifications.

CAS Number

1397-89-3

Molecular Formula

C₄₇H₇₃NO₁₇

Molecular Weight

924.08

Mechanism of Action

Amphotericin B associates with membrane sterols in mammalian and fungal cell membranes. Amphotericin B forms a pore in these membranes leading to essential ion leakage and ultimately, cell death.

Storage Conditions

2-8°C

Tariff Code

2941.90.1050

Spectrum

Amphotericin B is active against mammalian and fungal (molds and yeasts) cells. Amphotericin B is not toxic to bacteria due to their lack of sterols.

The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

• Candida albicans - 0.001 - 321 μg/mL
• Candida krusei - 0.001 - 16 μg/mL
• Coccidioides immitis - 0.0625 - 2 μg/mL
• Cryptococcus neoformans - 0.2 - 39 μg/mL
• Fusarium oxysporum - 0.75 - 125 μg/mL

Specifications:

TOKU-E植物生物学植物生物学，基因工程，改变植物生长特性。植物生物学是指植物的科学和研究。植物的特性和生长可以通过多种方式进行改变，包括基因工程和各种生长调节剂或激素的使用。可以通过农杆菌介导的转化或其他方法将DNA导入植物，  其中将质粒上的目标基因从农杆菌  细胞中转移  并整合到植物组织中。植物还易受细菌和真菌性植物病原体的侵害，而使用低毒性抗生素  和  抗真菌药可以控制或消除这些病原体  。