Bleomycin sulfate is a chemotherapeutic agent commonly used for Hodgkin’s lymphoma.Bleomycin is a mixture of Bleomycin A2 and Bleomycin B2. The approximate composition of A2:B2 is 2:1. The compound is water soluble.

TOKU-E also offers:

• Bleomycin (B053)
• Bleomycin A2 sulfate (B019)
• Bleomycin A5 hydrochloride (B004)
• Demethylbleomycin A2 sulfate, EvoPure^®(D023)

CAS Number

9041-93-4

Mechanism of Action

The exact mechanism of action Bleomycin sulfate is not well defined; however, it is thought to chelate metallic ions which decreases enzyme activity and stability. This effect is believed to cause the enzymes to react with oxygen, producing free radicals which create single stranded breaks in deoxyribose sugar.

Bleomycin's anticancer activities include the increase of caspase-3 and p53, and the inhibition of telomerase activity leading to apoptosis. The anti-cancer properties derives from its ability to effect DNA cleavage in cancer cells.

Storage Conditions

2-8 °C

Tariff Code

2941.90.5000

TOKU-E植物生物学植物生物学，基因工程，改变植物生长特性。植物生物学是指植物的科学和研究。植物的特性和生长可以通过多种方式进行改变，包括基因工程和各种生长调节剂或激素的使用。可以通过农杆菌介导的转化或其他方法将DNA导入植物，  其中将质粒上的目标基因从农杆菌  细胞中转移  并整合到植物组织中。植物还易受细菌和真菌性植物病原体的侵害，而使用低毒性抗生素  和  抗真菌药可以控制或消除这些病原体  。