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StressMarq/StressXpress® Ubiquitin Interact Detection Kit/SKT-132-20/20-assays

价格
¥7900.00
货号:SKT-132-20
浏览量:127
品牌:StressMarq
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商品描述

Overview:

ProductNameUbiquitinInteractDetectionKit
Description

Captureanddetectionofubiquitinbindingproteins

SpeciesReactivitySpeciesIndependent
PlatformSpinColumn
SampleTypesCelllysates,Tissue
AssayTypeBindingMatrix/QuantitativeWB(WesternBlot)
UtilityDetectionkitusedtocapture,detect,identifyandcharacteriseisolatedubiquitinbindingproteinsbyWesternblottingorproteomicanalysisinsamples.
IncubationTime1hour
NumberofSamples20samples
OtherResourcesKitBooklet,MSDS

Properties

StorageTemperature4ºC
ShippingTemperatureBlueIce
ProductTypeDetectionKits
AssayOverviewTheUbiquitinInteractDetectionkitfacilitatestheselectivecaptureanddetectionofubiquitinbindingandassociatedproteinsfromcelllysatesandtissueextracts.Thekitutilisesahighcapacity,highspecificityubiquitinmatrixtogetherwithaneasy-to-usepurificationsystemforefficientisolationofubiquitinbindingproteinswithminimalnon-specificbinding.Allowspurificationofmono-andpoly-ubiquitinbindingproteins,independentofchainlinkageorlength.AnalysisbyWesternblottingorproteomicmethodsenablesidentificationandassessmentofcapturedproteins.Kitcontainssufficientubiquitininteractmatrixtoperformupto20bindingassays.
KitOverview
ComponentNo.ItemQuantity/Size
SKC-132AStressXpress®ubiquitininteractmatrix(50%slurry)800µl
SKC-132BStressXpress®columns20tubes
SKC-132CStressXpress®collectiontubes20tubes
CiteThisProductUbiquitinInteractDetectionKit(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SKT-132)

BIOLOGicalDescription

AlternativeNamesPolyubiquitinBDetectionKit,RPS27ADetectionKit,UBA52DetectionKit,UBBDetectionKit,UBCDetectionKit,ubiquitinBDetectionKit
ResearchAreasCancer,Apoptosis,Autophagy,CardiovascularSystem,CellSignaling,Epigenetics,Neurodegeneration,Neuroscience,Post-translationalModifications,Ubiquitination
ScientificBackgroundThecovalentattachmentofubiquitintoproteins(ubiquitination)playsafundamentalroleintheregulationofcellularfunctionthroughbiologicaleventsincludingcellcycle,differentiation,immuneresponses,DNArepair,chromatinstructure,transcription,signaltransduction,endocytosis,apoptosisanddegradationbytheproteasome,autophagyandlysosomesystems.Assuchubiquitinsignallingandtheprocessesitmediatesareessentialforthenormalfunctioningofcellsanditsdysfunctionhasbeenimplicatedinwiderangeofdiseasesincludingcancer,neurodegeneration,cardiovascularandmetabolicdisorders(1,2).Thetypeofubiquitinmodification,(monoubiquitin,multiubiquitin,polyubiquitin),substrateproteinlysineresidue(s)modifiedand,inthecaseofpolyubiquitination,thechainlengthandlysinelinkagetypecontrolthefunctionandfateofubiquitinatedproteins.Inadditionallubiquitinmediatedpathwaysalsoutilisespecificubiquitinreceptorstofacilitatetheirregulation(3,4).Ubiquitinationisachievedthroughthreeenzymaticsteps.InanATP-dependentprocess,theubiquitinE1activatingenzymecatalysestheformationofareactivethioesterbondwithubiquitin,followedbyitssubsequenttransfertotheactivesitecysteineofaubiquitinE2carrierprotein.TheselectivityoftheubiquitincascadeforaparticularsubstrateproteinreliesontheinteractionbetweentheE2conjugatingenzyme(ofwhichacellcontainsrelativelyfew)andanubiquitinE3ligase,ofwhichover600havebeenidentifiedtodate.ThespecificE2-E3pairrequiredforubiquitinationofaparticularsubstrateproteininvivomayalsocontrolthetype,pointandlength/linkage(polyubiquitin)oftheubiquitinmodification(5).
References1.Fulda,S.,Rajalingam,K.&Dikic,I.EMBOmolecularmedicine4,545–56(2012).
2.Shaid,S.,Brandts,C.H.,Serve,H.&Dikic,I.Celldeathanddifferentiation20,21–30(2013).
3.Husnjak,K.&Dikic,I.Annualreviewofbiochemistry81,291–322(2012).
4.Komander,D.&Rape,M.AnnualReviewofBiochemistry81,203–229(2012).
5.Spasser,L.&Brik,A.AngewandteChemie(Internationaled.inEnglish)51,6840–62(2012).

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