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商品描述
Overview:
ProductName | Teprenone |
Description | HSP70Inducer |
Purity | >95%(GC) |
CASNo. | 6809-52-5 |
MolecularFormula | C23H38O |
MolecularWeight | 330.6 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Inducer |
Solubility | SolubleinDMSO(30mg/ml) |
Source | Synthetic |
Appearance | ColorlessOil |
SMILES | CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CCC(=O)C)/C)/C)/C)C |
InChI | InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+ |
InChIKey | HUCXKZBETONXFO-NJFMWZAGSA-N |
SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
CiteThisProduct | Teprenone(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-526) |
BIOLOGicalDescription
AlternativeNames | Geranylgeranylacetone,GGA,6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one |
ResearchAreas | Cancer,HeatShock,CellSignaling,Neuroscience |
PubChemID | 5282199 |
ScientificBackground | TeprenonecaninduceexpressionofHSP70,HSPB8,andHSPB1.InductionofHSP70expressionisprotectiveagainstthedevelopmentofvariousdiseases,suchasinflammatoryboweldisease,hypoxic/ischemicbraininjuryandspinalandbulbarmuscularatrophy(cytoprotectiveandanti-inflammatoryeffects)(1,2).ReportsindicatethatTeprenoneprotectsagainstNSAID-inducedgastricandintestinallesionsbyinductionofHSP70expression(2).OtherstudieshaveshownthatitinducesexpressionofHSPB8andHSPB1andreducestheformationofamyloidoligomersaswellasinsolubleaggregatesinHSPB5R120GTGmice(3,4). |
References | 1.KobayashiT.,OhtaY.,YoshinoJandNakazawaS.(2001)PharmacolRes.43(1):23-30. 2.SambroskiP.,GrzymislawskiM.(2015)AdvClinMed.24(3):525-530. 3.MarunouchiT.,InomataS.,SanbeA.,TakagiN.,TanonakaK.(2014)EurJPharmacol.730:1401-47. 4.SanbeA.,etal.(2009)PLoSOne.4(4):e5351. |
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