Overview:
ProductName | SulindacSulfone |
Description | Sulindacmetabolite |
Purity | >98% |
CASNo. | 59864-04-9 |
MolecularFormula | C20H17FO4S |
MolecularWeight | 372.41 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Inducer |
Solubility | Solubleto25mMinDMSO,3mMinethanol |
Source | Synthetic |
Appearance | Yellowsolid |
SMILES | CC1=C(C2=C(/C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O |
InChI | InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h4-10H,11H2,1-2H3,(H,22,23)/b17-9- |
InChIKey | MVGSNCBCUWPVDA-MFOYZWKCSA-N |
SafetyPhrases | Classification:Harmful.Maybeharmfulifinhaled,swallowedorabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
CiteThisProduct | SulindacSulfone(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-262) |
BIOLOGicalDescription
AlternativeNames | {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}aceticacid |
ResearchAreas | Cancer,Apoptosis |
PubChemID | 5472495 |
ScientificBackground | Sulindacisanonsteroidalanti-inflammatorydrugthatisknowntopreventrecurrenceandreducecolorectalpolyps.Itisaprodrugthatismetabolizedtoasulfideandsulfonederivativeinvivo.Themechanismofactionofbothistheselectiveinductionofapoptosis.Theanti-inflammatorypropertiesofsulindacaremediatedbyCOXinhibition(1,2). |
References | 1.FrahmS.,etal.(2004)CancerCellInt.4:4. 2.PiazzaG.A.,etal.(1997)CancerRes.57(12):2452-2459. |
ProductImages
ChemicalstructureofSulindacSulfone(SIH-262),aModulatesbeta-catenin-mediatedeffects.CAS#:59864-04-9.MolecularFormula:C20H17FO4S.MolecularWeight:372.41g/mol.
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