StressMarq蚂蚁淘在线

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Peptide Affinity Purified
Clonality	Polyclonal
Specificity	Detects 84.902 kDa.
Cite This Product	StressMarq Biosciences Cat# SPC-1082, RRID: AB_2709875
Certificate of Analysis	A 1:250 dilution of SPC-1082 was sufficient for detection of SIK1 (pThr182) in 10 µg of 293T cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names	SNF1LK Antibody, KID2 Antibody, MSK Antibody, myocardial SNF1 like kinase Antibody, QIK Antibody, Qin-induced kinase Antibody, Salt inducible kinase 1 Antibody, Salt-inducible protein kinase 1 Antibody, Serine threonine protein kinase SNF1 like kinase 1 Antibody, Serine threonine protein kinase SNF1LK Antibody, Serine/threonine-protein kinase SIK1 Antibody, Serine/threonine-protein kinase SNF1-like kinase 1 Antibody, Serine/threonine-protein kinase SNF1LK Antibody, SIK-1 Antibody, SIK1 Antibody, SIK1_HUMAN Antibody, SNF1 like kinase Antibody
Cellular Localization	Cytoplasm, Nucleus
Accession Number	NP_775490
Gene ID	102724428
Swiss Prot	P57059
Scientific Background	SIK1 (salt-inducible kinase 1), also known as SNF1LK or MSK, is a 783 amino acid protein that contains one UBA domain and one protein kinase domain and belongs to the Ser/Thr protein kinase family. Localized to both the nucleus and the cytoplasm, SIK1 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation. Additionally, SIK1 has a potential role in regulation of the G2/M cell cycle transition, as well as in inhibitory control of CREB protein function.

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ATTO 655

Overview:

High fluorescence yield
High thermal and photostability
Excellent ozone resistance
Quenched by electron donors
Very hydrophilic
Good solubility in polar solvents
Zwitterionic dye
Molar Mass: 634 g/mol

ATTO 655 Datasheet

ATTO 655 Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 663 nm

λ_em = 684 nm

ε_max = 1.25×10⁵

Φ_f = 0.30

τ_fl = 1.8 ns

Brightness = 37.5

Laser = 633 – 647 nm

Filter set = Cy®5

StressMarq细胞信号生物体中的每个细胞都暴露于来自其环境的数百种不同信号。单元可以以多种方式响应这些信号，并且独立地响应。但是，所有这些独立的动作在控制基本细胞活动的非常复杂且相互联系的通信路径中融合在一起。细胞外信号通过各种信号网络传输信息，最终在细胞核水平发挥作用。小区信令或蜂窝通信的三个阶段包括：接收信号信号转导单元内的响应倾向于起源于质膜水平的信号传导途径或网络包括G蛋白偶联受体，（非受体）酪氨酸激酶和离子调节通道等。尽管这些过程中涉及的关键调节分子有所不同，但信号的传输通常涉及一个共同的过程。靶蛋白的可逆磷酸化。两种不同的酶介导了这一点：蛋白激酶–磷酸化蛋白质（添加磷酸基团）蛋白质磷酸酶–使蛋白质脱磷酸（去除磷酸基团）细胞感知并正确响应其微环境的能力是发育，组织修复，免疫以及正常组织动态平衡的基础。细胞内信号传导事件实际上调节了所有细胞活动。细胞信息处理中的错误可能导致癌症，自身免疫性疾病和糖尿病等疾病。通过了解细胞信号传导的基本原理，研究人员希望能够开发出新药并对其进行选择性和有效治疗。细胞信号研究需要大量的生命科学产品。我们致力于开发最先进的研究产品，以协助研究细胞信号传导，包括单克隆抗体，多克隆抗体，抗体结合物，蛋白质，免疫测定法和小分子抑制剂。

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