Overview:
ProductName | SC79 |
Description | Aktkinaseactivator |
Purity | >97%(NMR) |
CASNo. | 305834-79-1 |
MolecularFormula | C17H17ClN2O5 |
MolecularWeight | 364.8 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Activator |
Solubility | Solubleto100mMinDMSO |
Source | Synthetic |
Appearance | Whitesolid |
SMILES | CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N |
SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
CiteThisProduct | SC79(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-512) |
BIOLOGicalDescription
AlternativeNames | SC-79,SC79,2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester |
ResearchAreas | CellSignaling |
ScientificBackground | SC79isanactivatorofAkt(proteinkinaseB).Specifically,ithasbeenshowntobindtheplecktrinhomology(PH)domainofAkt.ThismimicsthebindingofPhosphatidylinositol(3,4,5)-trisphosphates,whichinducesaconformationalchangeinAkt,thatenhancesphosphorylationandactivation. |
References | 1.JoH.,etal.(2012)Pro.Nat.Acad.Sci.USA.109(26):10581–10586. |
ProductImages
ChemicalstructureofSC79(SIH-512),aAktkinaseactivator.CAS#:305834-79-1.MolecularFormula:C17H17ClN2O5.MolecularWeight:364.8g/mol.
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