Overview:
ProductName | PMA |
Description | PKCkinaseactivator |
Purity | 99%(TLC) |
CASNo. | 16561-29-8 |
MolecularFormula | C36H58O8 |
MolecularWeight | 616.8 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Activator |
Solubility | SolubleinDMSO(25mg/ml),100%ethanol(25mg/ml),acetone,etherordimethylformamide;almostinsolubleinaqueousbuffers |
Source | Synthetic |
Appearance | Colorlessamorphousfilmorfoam |
SMILES | O=C(OC41C(C2/C=C(/CO)CC3(O)C(O)C(=C/C3C2(O)C(C)C1OC(=O)CCCCCCCCCCCCC)C)C4(C)C)C |
InChI | InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2, |
InChIKey | PHEDXBVPIONUQT-RGYGYFBISA-N |
SafetyPhrases | Classification:Skinirritation(Category2),H315SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H315Causesskinirritation.Precautionarystatements:P264Washskinthoroughlyafterhandling.P280Wearprotectivegloves.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse. |
CiteThisProduct | PMA(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-508) |
BIOLOGicalDescription
AlternativeNames | Phorbol12-myristate13-acetate |
ResearchAreas | CellSignaling |
PubChemID | 27924 |
ScientificBackground | PMA(Phorbol12-myristate13-acetate)isaphorbolester.ItisusedexperimentallyasareversIBLeproteinkinaseC(PKC)activator.Ithasbeenshowntobeapotenttumorpromoter. |
References | 1.MurphyT.V.,PrountzosC.,KotsonisP.,IannazzoL.,&MajewskiH.(1999).Euro.J.Pharm.381(1):77–84. 2.CastagnaM.,etal.(1982)J.Biol.Chem.257(13):7847–7851. |
ProductImages
ChemicalstructureofPMA(SIH-508),aPKCkinaseactivator.CAS#:16561-29-8.MolecularFormula:C36H58O8.MolecularWeight:616.8g/mol.
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