Overview:
ProductName | Doramapimod |
Description | p38MAPkinaseinhibitor |
Purity | >99%(HPLC) |
CASNo. | 285983-48-4 |
MolecularFormula | C31H37N5O3 |
MolecularWeight | 527.7 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Inhibitor |
Solubility | SolubleinDMSO |
Source | Synthetic |
Appearance | Whitesolid |
SMILES | C2=CC(=C1C=CC=CC1=C2NC(NC3=CC(=N[N]3C4=CC=C(C=C4)C)C(C)(C)C)=O)OCCN5CCOCC5 |
InChI | InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) |
InChIKey | MVCOAUNKQVWQHZ-UHFFFAOYSA-N |
SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
CiteThisProduct | Doramapimod(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-442) |
BIOLOGicalDescription
AlternativeNames | JNKInhibitorXVII,BIRB796,1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea |
ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
PubChemID | 156422 |
ScientificBackground | Doramapimodisahighlypotentandselectiveinhibitorofp38αMAPK.ItspecificallyblocksTNFαrelease. |
References | 1.PargellisC.,etal.(2002).NatStructuralBiol.9(4):268–272. |
ProductImages
ChemicalstructureofDoramapimod(SIH-442),ap38MAPkinaseinhibitor.CAS#:285983-48-4.MolecularFormula:C31H37N5O3.MolecularWeight:527.7g/mol.
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