Overview:
ProductName | DMPO |
Description | Spintrappingreagent |
Purity | >98% |
CASNo. | 3317-61-1 |
MolecularFormula | C6H11NO |
MolecularWeight | 113.16,13.16 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Agent |
Solubility | Solubleto100mMinethanolandto100mMinDMSO |
Source | Synthetic |
Appearance | ColorlessSolid |
SMILES | CC1(CCC=[N+]1[O-])C |
InChI | InChI=1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3 |
InChIKey | VCUVETGKTILCLC-UHFFFAOYSA-N |
SafetyPhrases | Classification:Harmful.Maybeharmfulifinhaled,swallowedorabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-Avoidcontactwithshinandeyes |
CiteThisProduct | DMPO(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-324) |
BIOLOGicalDescription
AlternativeNames | 2,2-Dimethyl-3,4-dihydro-2H-pyrrole1-oxide,5,5-Dimethyl-1-Pyrroline-N-Oxide,3,4-dihydro-2,3-dimethyl-2H-pyrrole1-oxide |
ResearchAreas | Cancer,OxidativeStress |
PubChemID | 1774 |
ScientificBackground | TheformationoffreerADIcalsandotherhighlyreactiveoxygenspecieshasbeenimplicatedinthepathogenesisofmanydiseasestates(1).TheABIlitytoidentifythesespeciesiscrucial,andspintrappinghasaccomplishedthisgoal.DMPO(5,5-dimethyl-1-pyrrolineN-oxide)isoneoftheleasttoxictocellsandanimals,andpossessesconvenientpharmacokinetics(uptake,distribution,metabolismandexcretion)inbiologicalsystems(2-6).RecentstudieshavedeterminedthatnitricoxidemaysubstantiallyaffectthequantitativedeterminationofDMPOadducts,andthereforeextracautionisrequiredwhenstudyinggenerationofthesespeciesinthepresenceofnitricoxideoritsradicals(1).DMPOadductscanbegeneratedwithproteinandDNAradicals(7). |
References | 1. ReszkaK.J.,etal.(2006)NitricOxide15:133-141. 2.RamirezD.C.,Gomez-MejibaS.E.,andMasonR.P.(2007)NatProtoc.2(3):512-522. 3.KhanN.,etal.(2003)FreeRadic.Biol.Med34:1473–1481. 4.HaseloffR.F.,etal.(1997)FEBSLett418:73–75. 5.SchaeferC.F.,JanzenE.G.,WestM.S.,PoyerJ.L.,andKosankeS.D.(1996)FreeRadic.Biol.Med21:427–436. 6.AnzaiK.,etal.(2003)Arch.Biochem.Biophys415:251–256. 7.ChatterjeeS.,Ehrenshaft,M.,Bhattacharjee,S.,Derterding,L.J.,Bonini,M.G.,Corbett,J.,Kadiiska,M.B.,TomerK.B.andMason,R.P.2009FreeRadic.Med.andBiol.46:454-461. |
ProductImages
ChemicalstructureofDMPO(SIH-324),aNitroneadductformation.CAS#:3317-61-1.MolecularFormula:C6H11NO.MolecularWeight:13.16g/mol.
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