Overview:
ProductName | 115-7C |
Description | Hsp70Activator |
Purity | >98% |
MolecularFormula | C23H22Cl2N2O5 |
MolecularWeight | 477.34 |
Properties
StorageTemperature | -20ºC |
ShippingTemperature | ShippedAmbient |
ProductType | Activator |
Solubility | SolubleinDMSO(20mg/ml) |
Source | Synthetic |
Appearance | WhiteSolid |
SMILES | CC1=C(C(NC(=O)N1CCCC(=O)O)c2ccc(cc2Cl)Cl)C(=O)OCc3ccccc3 |
InChI | InChI=1S/C23H22Cl2N2O5/c1-14-20(22(30)32-13-15-6-3-2-4-7-15)21(17-10-9-16(24)12-18(17)25)26-23(31)27(14)11-5-8-19(28)29/h2-4,6-7,9-10,12,21H,5,8,11,13H2,1H3,(H,26,31)(H,28,29) |
InChIKey | UHBVLBSCOSTTAV-UHFFFAOYSA-N |
SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
CiteThisProduct | 115-7C(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-123) |
BIOLOGicalDescription
AlternativeNames | 4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoicacid,SWO2 |
ResearchAreas | Cancer,HeatShock |
ScientificBackground | 115-7cactivatesHsp70ATPaseturnoverrateandpromotesHsp70substraterefolding.ItbindstotheIIAsuBDomainofDnaKandpromotestheDnaK-DnaJcomplex.EquivalentwithSW02. |
References | 1.Wisenetal.,(2010)ACSChem.Biol.,5:611-622. 2.Jinwaletal.(2009)J.Neurosci.29:12079. 3.Chafekaretal.(2012)ACSChemBiol.7:1556. 4.Walteretal.(2011)J.Biol.Chem.286:40486 |
ProductImages
Chemicalstructureof115-7C(SIH-123),aHsp70Activator.MolecularFormula:C₂₃H₂₂Cl₂N₂O₅.MolecularWeight:477.34g/mol.
ProductCitations(1)
OtherCitations
Hsp70MayBeaMolecularRegulatorofSchistosomeHostInvasion.
Ishida,K.andJollyE.R.(2016)PLoSNeglTropDis.10(9):e0004986.
PubMedID:27611863Applications:Invitroactivation