Clone/AB feature:

(#11P9)

Antigen:

Mouse Siglec-1

Stability:

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

Reconstitution:

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Description:

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: siglecs-1, -2, and -4, and a siglec-3/CD33-related subgroup (siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens. Relia Tech类似于我们在大肠杆菌中的蛋白质表达服务，我们还提供了围绕昆虫细胞中基因和蛋白质表达（尤其是信号蛋白质）的模块化服务系统。ReliaTech的“杆状病毒表达服务（BVS）”分为一系列步骤，这些步骤可以单独执行或组合执行，因此您可以选择实际需要的步骤。这些服务旨在充分满足从基因表达到蛋白质纯化的所有特定需求-从通过重组杆状病毒构建，高滴度重组杆状病毒生产，重组蛋白批量生产以及最终蛋白质纯化的基因克隆到杆状病毒转移载体开始。所有步骤均在无血清培养基中进行，以确保安全性并产生高纯度的重组蛋白。除常规项目更新外，您还将在每个服务步骤的最后收到进度报告。我们将根据您的授权逐步指导您继续进行。