RecombinantCXCL8(IL-8)

ORDERINGINFORMATIONORDERINGINFORMATION

CatalogNo.Size

50190P-22ug

50190P-1010ug

50190P-5050ug

50190P-100100ug

50190P-10001000ug

BACKGROUNDBACKGROUND

ThesmallcytokineCXCL8(alsoknownasIL-8)isknowntobeoneofthemostpotentchemoattractantmoleculesthat,amongseveralotherfunctions,isresponsIBLeforguidingneutrophilsthroughthetissuematrixuntiltheyreachsitesofinjury.IL-8isalsoapotentpromoterofangiogenesis.Intargetcells,IL-8bindstotwocellsurfacereceptors,CXCR1andCXCR2,andinducesaseriesofphysiologicalresponsesrequiredformigrationandphagocytosis,suchas

increaseofintracellularCa2+,exocytosis(e.g.histaminerelease),andrespiratoryburst.IL-8isa

memberoftheCXCchemokinefamily.ThegenesencodingthisandtheothertenmembersoftheCXCchemokinefamilyformaclusterinaregionmappedtochromosome4q.

DESCRIPTIONDESCRIPTION

Source:RecombinanthumanCXCL8isproducedinE.coli(accessionno.

P10145).

ProteinSequence:SAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

MolecularMass:8.386kDabyMassSpec.

Purity:>97%bySDS-PAGE

Activity:EC50=0.083nMdeterminedbymigrationofrecombinantCXCR1-expressingcells.

EndotoxinLevel:<0.01EUper1ugofproteinbyLALmethod.

Form:Lyophilized.

CarrierProtein:None.

PREPARATIONANDSTORAGEPREPARATIONANDSTORAGE

Reconstitution:Recommendedat100ug/mlinsteriledistilledwater.

StABIlityandStorage:12monthsfromdateofreceipt,-20oCto-70oC,assupplied.

1month,2oCto8oC,understerileconditionsafterreconstitution.

3months,-20oCto-70oC,understerileconditionsafterreconstitution.

Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.

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