RecombinantCCL7(MCP-3)

ORDERINGINFORMATIONRELATEDPRODUCTSORDERINGINFORMATIONRELATEDPRODUCTS

CatalogNo.Size#1112Anti-HumanCCR5Antibody50188P-22ug

50188P-1010ug

50188P-5050ug

50188P-100100ug

50188P-10001000ug

BACKGROUNDBACKGROUND

CCL7,alsoknownasMonocyteChemotacticProtein-3(MCP-3),isasecretedchemokinethatattractsmacrophages,monocytes,andeosinophilsduringinflammationandmetastasis.ItisamemberoftheC-Csubfamilyofchemokineswhicharecharacterizedbyhavingtwoadjacentcysteineresidues.Invivo,thisproteinisasubstrateofmatrixmetalloproteinase2(MMP2),anenzymethatdegradescomponentsoftheextracellularmatrix.ThegenethatencodesCCL7ispartofaclusterofC-Cchemokinefamilymembersonchromosome17q.CCL7bindstoCCR1,CCR2,andCCR3receptorsandappearstobeanantagoNISTfortheCCR5receptor.

DESCRIPTIONDESCRIPTION

Source:RecombinanthumanCCL7isproducedinE.coli(accessionno.

P80098).

ProteinSequence:QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL

MolecularMass:8.956kDabyMassSpec.

Purity:>97%bySDS-PAGE

Activity:EC50=0.91nMdeterminedbymigrationofrecombinantCCR2-expressingcells.

EndotoxinLevel:<0.01EUper1ugofproteinbyLALmethod.

Form:Lyophilized.

CarrierProtein:None.

PREPARATIONANDSTORAGEPREPARATIONANDSTORAGE

Reconstitution:Recommendedat100ug/mlinsteriledistilledwater.

StABIlityandStorage:12monthsfromdateofreceipt,-20oCto-70oC,assupplied.

1month,2oCto8oC,understerileconditionsafterreconstitution.

3months,-20oCto-70oC,understerileconditionsafterreconstitution.

Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.

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